Cenforce®

Cenforce

Brand(s): Cenforce

Manufacturer: Centurion Laboratories Ltd.

Generic name: Sildenafil Citrate

Formula: C28H38N6O11S

Pharmacologic Classifications: Type 5 Inhibitor

Availability: USA, UK, EU, Australia, Canada +

Cenforce Centurion Laboratories : About the Product

cenforce

Manufacturer

Cenforce one of the generic treatments for erectile dysfunction is manufactured by the Indian company, Centurion Laboratories . The company is located in Gujarat and was established in the year 1993, which makes the company about 24 years to date. But the company has been in the industry in 1984. Centurion Laboratories is a company focused on the manufacture of various pharmaceutical formulations primarily in the areas of erectile dysfunction, sexual enhancers, cosmetics (women), pain relief, cognitive neuropsychiatry, weight loss, brain activators, anti-epileptics, vertigo, Parkinson’s disease, hair care, herbal remedies, men and women’s health, and general health medicine.

The company is a small company employing about 60 people but employs the same standards in manufacturing and ethical practices as the large pharmaceutical companies. Centurion Laboratories manufactures products in several dosage formulations such as tablets, capsules, liquid formulations, and ointments. The company is ISO 9001:2000 accredited and also has the schedule T accreditation for its Ayurvedic remedies.

Products

Cenforce Centurion Laboratories is actually a product line composed of products containing the active ingredient sildenafil citrate which is highly effective in the treatment of erectile dysfunction. Products formulations available in the Cenforce product line include: Cenforce 100 mg, 200 mg, 120 mg, 130mg, 150 mg, 50 mg and 25 mg. The product line also includes several special formulations like oral jelly, and sildenafil combination drugs like Cenforce Super Active, Cenforce Professional and Cenforce D 160 mg (sildenafil 100 mg and dapoxetine 60 mg)

Availability

Cenforce products, since manufactured in India, may be found at the local drugstores. Some countries also have Cenforce available locally (mostly in India’s neighboring Asian countries). But the large fraction of the sale of Cenforce comes from the online sale of the products. There are a number of vendors which have Cenforce available for purchase online, so buyers can easily avail of Cenforce even if they are not in India.

But as buyers, you should choose your vendor carefully because there are a lot of scamming stores on the internet nowadays. If you feel that there is something wrong with the online site you are browsing, then do not proceed with your purchase. Look for online stores which have good user reviews not on the site themselves, but in review sites, third-party sites, independent sites, and online forums which are not in any way affiliated with the online stores. There are also some users with suggestions on the good online stores to buy from, so it is good to be updated with the user recommendations found on several online forums.

What is Cenforce 100?

Cenforce 100

Cenforce 100 is a generic drug marketed by Centurion Laboratories Pvt. Ltd. It has sildenafil citrate as the main active pharmaceutical ingredient. It is commonly prescribed for the management of Erectile Dysfunction (ED) in men. ED is a condition whereby men are unable to achieve a satisfactory erection. It is one of the most common diseases of sexual disorders which can be easily managed on an outpatient basis. Cenforce 100 is a prescription only medication available in the strength doses of 50 and 100 mg. It has to be taken only after proper consultation with a doctor and, like all medications, has some adverse effects which can be minimized if certain precautions are taken. No doubt, the introduction of sildenafil has revolutionized the treatment of ED, but over the years, different companies have released a myriad of generic brands and more data from clinical studies concerning sildenafil have emerged. It is imperative to take all of this into consideration before choosing any particular brand of sildenafil.

What is Cenforce 150?

Cenforce 150

Cenforce 150 mg is a promising generic drug produced by Sunrise Remedies for the treatment of erectile dysfunction. Men who have impotence use it on as needed basis. The recommended dosage of Cenforce is 120mg. The effect of this drug lasts for 4 -6 hours. Cenforce brand is to be taken one hour before sexual intercourse. It is advisable to drink a glass of water while consuming. Also, Cenforce 150 should not be taken with alcohol or fatty meals. The available dosage form of Cenforce 150 are pills and oral jelly. If you have liver or kidney diseases, you should not take erectile dysfunction drugs. In addition, the drug may interact with nitrates and isosorbide mononitrate. The drug is not suitable for women and children. There are some side effects as a headache, gastric disturbances and nausea have been reported with Cenforce 150. But these effects are mild and last for a few hours.

What is Cenforce 200?

Cenforce 200

Cenforce 200 is a 200 mg Sildenafil-containing product indicated for patients with erectile dysfunction. The product is another output from Centurion Laboratories , a pharmaceutical company native to India. Centurion Laboratories specializes in medicines for Erectile Dysfunction (ED) and for drugs for men’s health.

Sildenafil citrate is the component of Cenforce 200 which makes it a potent medication for ED. There are a lot of sildenafil products in the market, and Cenforce 200 is one of those new generic meds manufactured to serve as a cheaper substitute for the expensively priced brand name sildenafil treatments.

According to the vendor information, Cenforce 200 is one of the “newest” and the most powerful ED drug made by the company yet. The recommended initial dose for sildenafil is only anywhere between 25 mg to 100 mg, according to studies like the ones by Merry et.al., “Interaction of sildenafil and indinavir when co-administered to HIV-positive patients”. The 200 mg, dose, however, is still within acceptable means (“Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication” by Zusman et.al.), but there are studies indicating that some adverse effects are associated with the high dosing of the drugs, so caution should be exercised when taking the 200 mg variant as though it may be safe, taking sildenafil at such a high dose still entails risk.

Scientific Studies on Sildenafil Citrate

In the study by H. George Nurnberg et al. titled “Efficacy of sildenafil citrate for the Treatment of Erectile Dysfunction in Men Taking Serotonin reuptake inhibitors” the goal was to value the effect of sildenafil citrate in the treatment of erection problems in patients taking antidepressants (serotonin-reuptake-inhibitor). This study is a sub-analysis of information about placebo controlled, double blinded trials which lasted for 12-26 weeks. Patients were taking sildenafil (5-200 mg/day) or placebo and antidepressants (serotonin-reuptake-inhibitor). Results were dependent on questions about the ability to achieve and maintain an erection, ejaculation frequency, and sexual desire. There was an improvement in the ability to maintain erection and ejaculation frequency in patients taking sildenafil and antidepressants (serotonin-reuptake-inhibitor) than patients taking a placebo. In brief, we can conclude that there is an improvement in erectile dysfunction in patients taking sildenafil with antidepressants (serotonin-reuptake-inhibitor).

Another study titled “Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents* a randomized controlled trial” by Thomas G. Pickering et al. (2004) is worth mentioning. The goal of this study was to value the effect of sildenafil citrate in treatment erectile dysfunction in 568 patients taking many antihypertensive drugs. These patients were taking sildenafil or placebo randomly for six weeks. But in the following six weeks, all patients took sildenafil. The results were dependent on questions about frequency of erection and penetration, and improvement in intercourse. After six weeks, there was an improvement in erection and intercourse in patients taking sildenafil than those who are taking a placebo. At week 12, all patients had an improvement in intercourse and erection. In brief, we can say that sildenafil is effective in the treatment of erectile dysfunction in patients taking medications for hypertension.

Also, there is a related study named “Ocular Safety in Patients Using Sildenafil Citrate Therapy for Erectile Dysfunction” by Alan Laties MD, and Ira Sharlip MD (2006). The goal of this study was to evaluate effects of sildenafil on visual function. Sildenafil citrate is a potent inhibitor of phosphodiesterase type 5, but it is a very weak inhibitor of phosphodiesterase type 6 which presents in photoreceptors of rod and cone. Several visual symptoms as blurred vision, increased sensitivity to light, and colored vision has been noticed in patients taking sildenafil. They are likely to occur if a patient is consuming higher doses. But eventually, visual function studies of visual function in people with good health and patients with ocular diseases found that sildenafil has no effect on ocular circulation, visual fields, retina, and acuity of vision.

Interactions

Sildenafil Citrate 120

Clinically significant interactions exist between sildenafil citrate and some drugs for example nitrates, macrolides, some antifungal agents, antiviral agents, and other antibiotics. Many disease conditions are also affected by this agent such as heart diseases, hepatic failure, epilepsy and seizures, kidney diseases, lung diseases and ocular issues. Food usually does not affect the levels of sildenafil citrate in the plasma but consuming alcohol with sildenafil can result in hypotension and dizziness. There are high chances of losing balance and tripping over because of postural hypotension induced by alcohol. Another interaction that comes under alcohol and food interaction is sildenafil interaction with grapefruit and grapefruit juice. It was revealed in some studies that grapefruit or its juice, when used in excessive or abnormal amounts, can raise the plasma drug concentrations of sildenafil citrate which can be very dangerous especially in this case because the patient would already be receiving double strength of the usual dose. Cardiac risks are higher in patients with a past history of cardiac issues and the use of sildenafil is not advisable in such patients. Clearance of sildenafil depends majorly on the hepatic route and some proportion is cleared through renal route. Diseases affecting any of these organs can increase the plasma concentration of sildenafil and might result in toxic levels of this drug in the body. Ocular damages can worsen if sildenafil treatment is started without an eye examination of the patient.

Warnings

There is no indication for the use of this drug in women. This drug is indicated for adult men and should be used when needed. The pregnancy category of this drug is B. It is not recommended for use in women with childbearing potential. Evidence of toxicity to the unborn child, teratogenicity, fetotoxicity and embryotoxicity were not found when animal trials were conducted on rats and rabbits. The risk still remains and there can be unwanted and unexpected outcomes if this product is ingested by a woman. There are some references that this drug is excreted into the breast milk.

Recommended Doses

dose for cenforce

The recommended initial dose for Cenforce is 50 mg, but the dose may be increased to 100 mg for a better effect, or it may also be lowered to 25 mg for those with additional medical considerations. There is no recommended duration of treatment or duration of therapy for taking Cenforce, as currently, the drug is recommended to be taken as needed only, and without exceeding a single dose in a day.

Side effects

cenforce side effects

There are many side effects related to the use of Cenforce and they may occur regardless of dosing. The patients are reporting side effects like headache, flushing, and hot flushes. Also, there were reports of side effects such as dyspepsia, nasopharyngitis, and rare side effects like conjunctival hyperemia and eyelid edema.

Aside from these mentioned by studies, though, there are still more side effects correlated with the usage of Cenforce products. Vendors and manufacturers issue warnings for Cenforce probable side effects like dizziness, nausea, vomiting, tachycardia, arrhythmia, allergic reactions, vision changes, prolonged erections (painful and lasting for more than 4 hours), and seizures.

Customer Reviews

Compared to other generic brands of sildenafil, reviews concerning Cenforce were scarce in numbers and quite polarized. One user shared his opinion that Cenforce 100 is not very good and contains lots of undisclosed chemical components. He has tested other generic brands of sildenafil though, not Cenforce 100. Another user states that he “never tried it, but would like to.” However, from his comments, it seems he confused sildenafil with dapoxetine.

Conversely, on another site, James Burkhead is happy with effects of Cenforce 200. He was looking for an alternative to Viagra and ordered Cenforce 200. He finds it “quite affordable and incredible medicine!” Similarly, Carter Collins also thinks that choosing Cenforce was the best decision and its rates are reasonable.

The reviews about Cenforce 150 are few and polarized. It is hence difficult to judge its true potential. It is highly possible that the positive opinions given by the users are fabricated and placed by the manufacturers to boost the image. It is recommended to get Cenforce 150 only after ensuring it worked for actual customers.